I'd personally like to go totally mouseless, but sadly there is far too much software out there whose keyboard support is incompetent at best and outright malicious at worst. For example, there is one program I have used that actually disables Ctrl-X, Ctrl-C and Ctrl-V for cut, copy and paste.
I try not to use the mouse. When I first experienced shoulder problems, I switched the mouse over to my left hand, and have used it there since. I barely touch it.
I've the nipple or touchpad on my Thinkpad for pointer use. The nipple has excellent placement, but it requires quite a bit of pressure compared with the touchpad, that I can lightly touch. So I sadly forsake it.
I'm all into keyboard shortcuts, and totally rely on them. I've learnt to barely use a pointer especially when I'm using the web browser.
I don't think I've ever had a particluar problem using the mouse with my wrist and fingers unlike some. I did find that it felt too far away when used to the right of the numpad on the keyboard. And that it can be a distraction from hand placement on the keyboard. I can also get into bad posture when using the mouse - I can be lopsided, get into other bad habits. They are a wonderfully simplistic and elegant device though.
Some keyboard tips:
Use Opera with SHIFT and arrows, to navigate web page links (you might have to turn that setting on)
Set up keyword shortcuts for quick search engine access - in Firefox and Chrome right click the keyword search field and add a search with a keyword. For something like Google you can add a keyword of g. Then to use it use CTRL+L to go straight to the location bar, then type 'g your search term' and hit enter. This feature was borrowed from Opera too. You loose out on some autocompletion, but you can set these up for multiple sites.
In firefox use ' to find text only in links. This is good for quickly jumping to site nav links, and search engine results.
CTRL + PGUP/PGDN to switch between tabs.
ALT + LEFT ARROW or BACKSPACE to go back a page.
CTRL + T - to open a new tab
CTRL + W - to shut a tab
I could pretty much use Apple's Tiger OS without the mouse. The last time I tried Ubuntu's unity I had to use the mouse for some operations. And as you say, keyboard support seems to be a bit irratic and inconsistant between applications and OSs.
If you do some or all of the above, you'll find you can cut down drastically upon your reliance upon the mouse.
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Physicians deafen our ears with the Honorificabilitudinitatibus of their heavenly Panacaea, their sovereign Guiacum.