I use Colemak layout for my English keyboard. The Ctr+S shortcut is not working, but other like Ctr+C, Ctr+V work fine.
But when I change the language to another, like Russian or Ukrainian, shortcuts start to work as for QWERTY layout. So, any time when I need Ctr+P, Ctr+S, Ctr+F or any other combination, which has different position of letters with Colemak - shortcuts don't work.
Note, that I have no QWERTY layout installed, only the Colemak. I did not try, but I suppose that Dvorak users sholud have the same problem.
Any ideas how to resolve this?