Hi there,
It is my second day of Colemak and typing is pain in the ass right now. :) Hope it will improve in a few weeks.
Anyway, there is a solution to the hotkey problem if you use AutoHotKey.
First of all, you can designate your own hotkey for switching between two or more layouts,
https://www.autohotkey.com/forum/viewtopic.php?t=27029
You can recognize which layout is in effect, and designate hotkeys accordingly.
https://www.autohotkey.com/forum/viewto … 092#169092
Thus you can do this: when you press Ctrl + s in standard English Layout, Ctrl + s is sent. When you press Ctrl + r in Colemak Layout, Ctrl + s is sent. Hence, you can type in Colemak or Dvorak while maintaining all the hotkeys in QWERTY.
Hope this is useful. :)