I've been test-driving Colemak for a month or so on my laptop, (I still have to use QWERTY on my desktop.) and it's not that bad.
Even though I have to look down on the keyboard a bit more now, it does seem more comfortable to have more commonly-used letters on the home row while, at the same time, not forcing you to relearn everything like what happened to me with trying to learn Dvorak a year or two ago.
I still use that backspace key a lot. I think it's so ingrained in me my relationship with the capslock key being just that, that I'm not used to it.
I would like to see that delete key move closer, as well, but I suppose you would have to move the arrow keys closer, as well, which is not likely.